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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
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Acute-onset postoperative endophthalmitis caused by multidrug-resistant Klebsiella pneumoniae

Shekhar Sanghi1, Avinash Pathengay1, Animesh Jindal1

  • 1Department of Ophthalmology, L V Prasad Eye Institute, GMR Varalakshmi Campus, Visakhapatnam, Andhra Pradesh, India.

Clinical Ophthalmology (Auckland, N.Z.)
|September 27, 2014
PubMed

Insights

Intravitreal imipenem shows promise for treating severe eye infections caused by multidrug-resistant Klebsiella pneumoniae. This treatment approach may be effective against this aggressive form of postoperative endophthalmitis.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Microbiology

Background:

  • Postoperative endophthalmitis can be caused by multidrug-resistant bacteria.
  • Klebsiella pneumoniae is a significant pathogen associated with severe intraocular inflammation and rapid disease progression.

Purpose of the Study:

  • To report the outcomes of using intravitreal imipenem for treating multidrug-resistant Klebsiella-related postoperative endophthalmitis.

Main Methods:

  • Observational case series.
  • Treatment involved intravitreal administration of imipenem.
  • Data collected from three patients between 2013 and 2014.

Main Results:

  • Intravitreal imipenem was administered to three patients with severe endophthalmitis.
  • The study observed the outcomes of this treatment approach.

Conclusions:

  • Intravitreal imipenem may serve as a viable treatment option for postoperative endophthalmitis caused by multidrug-resistant Klebsiella.
  • Further research is warranted to confirm the efficacy and safety of this therapeutic strategy.
Keywords:
Klebsiella pneumoniaeimipenemmultidrug resistancepostoperative endophthalmitis

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