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Maintaining persistence and adherence with subcutaneous growth-hormone therapy in children: comparing jet-delivery

Helen A Spoudeas1, Priti Bajaj2, Nathan Sommerford3

  • 1London Centre for Paediatric Endocrinology, University College London, London, UK.

Patient Preference and Adherence
|September 27, 2014
PubMed

Insights

The ZomaJet jet-delivery device significantly improved persistence and adherence in children receiving growth hormone (GH) therapy compared to traditional needle-based devices. Offering jet-delivery options may enhance treatment outcomes.

Area of Science:

  • Pediatric endocrinology
  • Pharmacotherapy adherence
  • Medical device technology

Background:

  • Subcutaneous growth hormone (GH) therapy in children often suffers from suboptimal persistence and adherence.
  • Needle-based delivery devices are the conventional method for administering GH.

Purpose of the Study:

  • To evaluate the impact of the ZomaJet jet-delivery device on medication-taking behaviors in children undergoing GH therapy.
  • To compare the persistence and adherence rates between ZomaJet and traditional needle-based GH delivery devices.

Main Methods:

  • Retrospective cohort study utilizing a UK nationwide database of GH home-delivery schedules (2010-2012).
  • Analysis included 6,061 children (≤18 years) receiving somatropin via ZomaJet or six needle-based GH brands.
  • Persistence measured by time between first and last home deliveries; adherence analyzed by proportion of days covered for ZomaJet users.

Main Results:

  • Significantly longer persistence with GH therapy was observed in ZomaJet users (599 days) compared to needle-based devices (535 days; P<0.001).
  • The majority of ZomaJet patients (58%) were adherent; only 5% of all patients switched GH brands.
  • ZomaJet users tended to use the device for longer durations before considering a switch.

Conclusions:

  • Jet-delivery devices, such as ZomaJet, may be a crucial strategy for improving persistence in pediatric GH therapy.
  • Offering jet-delivery devices could lead to better clinical outcomes and cost-efficiency in managing childhood GH deficiency.
  • The choice of delivery device significantly influences patient adherence and long-term treatment success.
Abstract

Keywords:
adherencechildrengrowth hormonejet deliverypersistence

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