Related Experiment Video
Updated: Apr 23, 2026
Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction
Published on: October 14, 2016
In-hospital outcomes after primary percutaneous coronary intervention according to left ventricular ejection fraction
Hossein Vakili1, Roxana Sadeghi2, Parisa Rezapoor3
1Associate Professor, Department of Interventional Cardiology AND Cardiovascular Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Insights
Left ventricular ejection fraction (LVEF) below 50% after primary percutaneous coronary intervention (pPCI) for ST-segment elevation myocardial infarction (STEMI) is linked to worse outcomes. Certain patient characteristics predict these adverse events and death.
Area of Science:
- Cardiology
- Interventional Cardiology
- Clinical Outcomes Research
Background:
- Primary percutaneous coronary intervention (pPCI) aims to restore blood flow and improve survival in ST-segment elevation myocardial infarction (STEMI) patients.
- Left ventricular ejection fraction (LVEF) is a critical predictor of clinical outcomes in STEMI.
- The study investigates the relationship between LVEF, patient characteristics, and mortality following pPCI.
Purpose of the Study:
- To evaluate the association between LVEF and in-hospital outcomes in STEMI patients undergoing pPCI.
- To identify patient characteristics that predict adverse events and death in this population.
Main Methods:
- Prospective cohort study of 304 patients undergoing pPCI between 2009 and 2011.
- Assessment of the association between LVEF (categorized as ≤25%, 25%-50%, and ≥50%) and in-hospital outcomes.
- Analysis of baseline characteristics and their correlation with mortality.
Main Results:
- LVEF was categorized as ≤25% (7.6%), 25%-<50% (49.3%), and ≥50% (42.1%).
- Significant differences in cardiogenic shock (2.3%) and death (7.2%) were observed across LVEF groups.
- Factors like older age, pulmonary edema, low blood pressure, shock, and poor reperfusion were associated with increased mortality (P < 0.05).
Conclusions:
- LVEF ≤ 50% is associated with a higher incidence of in-hospital adverse events after pPCI.
- Specific patient characteristics are strongly correlated with both reduced LVEF and increased risk of death post-pPCI.
Background:
The primary objective of primary percutaneous coronary intervention (pPCI) in patients with acute ST-segment elevation myocardial infarction (STEMI) is not only to restore the blood flow in the infarct-related artery, but also to save the patients' quality and duration of their life. Since left ventricular ejection fraction (LVEF) is a known predictor of clinical outcomes in STEMI patients, the possible association between characteristics of a large group of patients who undergo pPCI with LVEF and death was evaluated.
Methods:
This prospective cohort study included 304 patients who had undergone pPCI between 2009 and 2011. The association between LVEF and in-hospital outcomes of patients was assessed.
Results:
LVEF ≤ 25%, 25% < LVEF < 50%, and LVEF ≥ 50% were presented in 23 (7.6%), 150 (49.3%), and 128 (42.1%) of the patients, respectively. Three patients (0.01%) died before echocardiography. There was no significant difference among aforementioned three groups regarding baseline characteristics, except age (P = 0.012) and sex (P = 0.016). Cumulative number of cardiogenic shock and death were 7 (2.3%) and 22 (7.2%), respectively; with significant differences between three LVEF groups. Age more than 70 years old, pulmonary edema, systolic blood pressure < 100 mm Hg, shock, post-PCI thrombolysis in myocardial infarction (MI) flow grade, corrected thrombolysis in MI frame count, angiographic success and ST-segment resolution showed significant association with death (P < 0.050).
Conclusion:
This study not only demonstrates that LVEF ≤ 50% is associated with a higher incidence of in-hospital adverse events, but also identifies characteristics that are strongly correlated with the risk of LVEF ≤ 50% and death after pPCI.
More Related Videos
08:19Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs
Published on: July 12, 2022
14:35Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
Published on: April 17, 2021
