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A Practical Testing Battery to Measure Neurobehavioral Ability among Children with FASD
Wendy O Kalberg1, Philip A May2, Jason Blankenship1
1Center on Alcoholism, Substance Abuse and Addictions, The University of New Mexico, Albuquerque, New Mexico, USA.
Aims:
To determine a brief, practical battery of tests that discriminate between children with a fetal alcohol spectrum disorder (FASD) and unexposed controls.
Design:
Children received dysmorphology exams, a targeted battery of cognitive and behavioral tests, and their mothers were interviewed about maternal risk factors. Children diagnosed with an FASD and children unexposed to alcohol prenatally were compared on cognitive/behavioral test results.
Setting:
A community in The Western Cape Province of South Africa.
Participants:
Sixty-one, first grade children with FASD and 52 matched normal controls.
Measures:
Statistical analyses of maternal drinking behavior and their child's test performance.
Findings:
Self-reported maternal drinking patterns before during and after pregnancy were used to confirm prenatal exposures to alcohol in the group of children diagnosed with FASD. With this sample of children diagnosed with FASD and completely unexposed controls, the adverse effects of maternal drinking on children's performance are reported. Results of the battery of standardized cognitive and behavioral tests indicate highly significant differences (p ≤ .001) between groups on: intelligence, perceptual motor, planning, and logical, spatial, short term, long term, and working memory abilities. Furthermore, a binary logistical regression model of only 3 specific cognitive and behavioral tests, including Digit Span A+B (Wald = 4.10), Absurd Situation (Wald = 3.57), and Word Association (Wald = 4.30) correctly classified 79.1% of the child participants as FASD or controls.
Conclusions:
A brief, practical set of tests can discriminate children with and without FASD and provide useful information for interventions for affected children.
