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Kallikrein-kinin in stem cell therapy.
Julie Chao1, Grant Bledsoe1, Lee Chao1
1Julie Chao, Grant Bledsoe, Lee Chao, Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, United States.
World Journal of Stem Cells
|September 27, 2014
Summary
The kallikrein-kinin system influences stem cell behavior, offering protection against organ damage. Genetically modified stem cells show enhanced protective effects, suggesting a new approach for stem cell therapy.
Area of Science:
- Physiology
- Biochemistry
- Regenerative Medicine
Background:
- The tissue kallikrein-kinin system (TKKS) has diverse roles in cardiovascular, renal, and nervous systems.
- TKKS influences the behavior of various stem cell types, including mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs).
Purpose of the Study:
- To investigate the role of TKKS in modulating stem cell functions.
- To explore the potential of TKKS in enhancing stem cell-based therapies for tissue repair and regeneration.
Main Methods:
- Review of existing literature on TKKS and stem cell interactions.
- Analysis of studies involving genetically modified MSCs and EPCs with tissue kallikrein.
- Examination of animal models of cardiovascular, renal, and neural damage.
Main Results:
- TKKS stimulation of stem cells inhibits apoptosis, inflammation, fibrosis, and oxidative stress, while promoting neovascularization.
- Genetically modified MSCs and EPCs exhibit increased resistance to apoptosis and enhanced protective effects in injury models.
- Plasma kallikrein-kinin system activation can promote EPC recruitment, but its product, cleaved high molecular weight kininogen, can impair EPC activity.
Conclusions:
- Kallikrein-kinin modulation of stem cells presents a promising strategy for regenerative medicine.
- Enhancing stem cell therapy efficacy through kallikrein-kinin pathways offers a novel therapeutic approach for various human diseases.
Keywords:
BrainEndothelial progenitor cellsHeartKidneyKininMesenchymal stem cellsNeural stem cellsPlasma kallikreinTissue kallikreinMore Related Videos
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