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Related Concept Videos

iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Stem Cell Culture01:17

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Somatic to iPS Cell Reprogramming01:29

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Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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Renal stem cell reprogramming: Prospects in regenerative medicine.

Elvin E Morales1, Rebecca A Wingert1

  • 1Elvin E Morales, Rebecca A Wingert, Department of Biological Sciences and Center for Zebrafish Research, University of Notre Dame, Notre Dame, IN 46556, United States.

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PubMed
Summary

Stem cell therapy offers a promising future for kidney disease patients, potentially reducing transplant rejection and dialysis needs. Research focuses on safe and efficient reprogramming of cells for regenerative medicine.

Keywords:
DifferentiationInduced pluripotent stem cellKidneyRegenerationRenal progenitorReprogrammingStem cell

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Area of Science:

  • Nephrology
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Kidney disease affects millions globally, necessitating lifelong dialysis or transplantation.
  • Current treatments for kidney disease have limitations, including tissue rejection and limited supply.
  • Reprogramming patient cells into pluripotent stem cells offers a potential solution to these challenges.

Purpose of the Study:

  • To review recent advances in induced pluripotent stem cell (iPSC) technologies for kidney disease.
  • To explore strategies for generating renal progenitor cells.
  • To discuss the implications of these advancements for cell-based regenerative therapies.

Main Methods:

  • Review of current literature on induced pluripotent stem cell technologies.
  • Analysis of strategies for renal progenitor cell generation.
  • Discussion of genetic control and small molecule modulation in reprogramming.

Main Results:

  • Recent advances in iPSC technology show promise for kidney regeneration.
  • Successful strategies for renal progenitor generation have been identified.
  • Understanding genetic control is key to efficient reprogramming.

Conclusions:

  • Stem cell therapy holds significant potential for renal replacement in kidney disease.
  • Overcoming hurdles in cell fidelity, safety, and reprogramming efficiency is crucial for clinical application.
  • Further research into genetic control and reprogramming methods will advance cell-based regenerative therapies for kidney disease.