Diffusion of rat atrial natriuretic factor in thermoreversible poloxamer gels

Concentrated poloxamer 407 solutions display a negative thermorheological behaviour, resulting in a higher viscosity at body temperature than below. This could be exploited for various controlled delivery applications including the nasal delivery of peptides. The rheology of the gel and the diffusion of ANF were studied as a function of temperature. A theory is proposed, according to which a temperature rise creates an intermicellar network resulting in a viscosity increase. The diffusion of the drug appears limited only by the presence of micelles which lengthens the diffusion pathways and is not significantly influenced by the formation of this network.