Related Experiment Video
Updated: Apr 23, 2026

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
Published on: August 1, 2025
Trajectories of Marijuana Use Beginning in Adolescence Predict Tobacco Dependence in Adulthood
Judith S Brook1, Jung Yeon Lee1, David W Brook1
1a Department of Psychiatry , New York University School of Medicine , New York , New York , USA.
Background:
Although the "stage theory" suggests that marijuana use occurs after the initiation of tobacco smoking, substantial evidence exists that they often occur concurrently, and that the use of marijuana may influence the use of tobacco.
Methods:
This study uses trajectory analysis to examine the relationship between marijuana use beginning in adolescence and adult tobacco dependence in a 5-wave longitudinal study (mean ages in each wave: 14, 19, 24, 29, and 32). The sample consisted of 816 participants (52% African Americans, 48% Puerto Ricans), of whom 60% were females. Logistic regression analyses were conducted to predict later tobacco dependence from earlier trajectories of marijuana use.
Results:
A higher Bayesian posterior probability (BPP) for the chronic marijuana use trajectory group (odds ratio [OR]=10.93, P<.001; adjusted OR [AOR]=10.40, P<.001), for the increasing marijuana use trajectory group (OR=6.94, P<.001; AOR=6.73, P<.001), and for the moderate marijuana use trajectory group (OR=3.13, P<.001; AOR=3.18, P<.001) was associated with an increased likelihood of being dependent on tobacco compared with the BPP of the no or low marijuana use trajectory group.
Conclusions:
The results underscore the value of considering multiple patterns of marijuana use within a person-centered approach. Thus, it would be appropriate for marijuana cessation programs to incorporate the prevention, assessment, and cessation of tobacco use in their health promotion strategies.
Related Concept Videos
Drug Dependence
Stress Prevention and Stress Management Techniques IV
Stimulants
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
Substance Use Disorders Affecting Sleep
Understanding the concepts of physical dependence,...
Drug Abuse and Addiction: Pharmacological Phenomena
Influence of Parents and Peers on Identity
Parental Influence on Identity Development
Parents serve as primary guides and managers in an adolescent's life, offering support instrumental in decision-making and personal growth....

