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Related Concept Videos

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

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Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
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Varicose Veins II: Diagnostic Studies and Interprofessional Care01:26

Varicose Veins II: Diagnostic Studies and Interprofessional Care

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Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...
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Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
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Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

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5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Related Experiment Video

Updated: Feb 18, 2026

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
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Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

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Chemoembolization and radioembolization.

Bruno Sangro1

  • 1Clinica Universidad de Navarra, and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Avda, Pio XII 36, 31008 Pamplona, Spain.

Best Practice & Research. Clinical Gastroenterology
|September 28, 2014
PubMed
Summary
This summary is machine-generated.

Chemoembolization and radioembolization are key treatments for hepatocellular carcinoma when curative options fail. While both reduce tumors, chemoembolization uses beads for drug delivery, and radioembolization uses internal radiation, targeting different patient stages.

Keywords:
Drug-eluting beads, DEBRadioembolization, RESelective Internal Radiation Therapy, SIRTTransarterial chemoembolization, TACEYttrium

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Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization
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Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization

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Area of Science:

  • Interventional Radiology
  • Hepatobiliary Oncology
  • Medical Treatments

Background:

  • Hepatocellular carcinoma (HCC) management often relies on palliative treatments for unresectable cases.
  • Transplantation, resection, and ablation are curative but not universally applicable.
  • Chemoembolization and radioembolization are primary locoregional therapies for advanced HCC.

Purpose of the Study:

  • To compare the mechanisms and patient selection for chemoembolization and radioembolization in HCC.
  • To review the evidence supporting the use of these techniques in different stages of HCC.
  • To highlight ongoing research in optimizing treatment selection.

Main Methods:

  • Review of chemoembolization (including drug-eluting beads) and radioembolization mechanisms.
  • Analysis of evidence grading for treatment indications in early, intermediate, and advanced HCC stages.
  • Discussion of patient selection challenges and ongoing clinical trials.

Main Results:

  • Chemoembolization induces ischemia and increases drug exposure; radioembolization delivers internal irradiation.
  • Drug-eluting beads offer a standardized approach to chemoembolization, achieving cytoreduction and potential ablation.
  • Grade 1 evidence supports chemoembolization for early/intermediate HCC; Grade 2 supports radioembolization for intermediate/advanced HCC.

Conclusions:

  • Both chemoembolization and radioembolization are vital for unresectable HCC, with distinct mechanisms and indications.
  • Optimizing patient selection for each modality remains an active area of clinical research.
  • Ongoing trials aim to refine the use of these interventional techniques for improved HCC outcomes.