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StaR Child Health: developing evidence-based guidance for the design, conduct and reporting of paediatric trials

William Van't Hoff1, Martin Offringa2,

  • 1Somers Clinical Research Facility, Great Ormond Street Hospital NHS Foundation Trust, London, UK.

Archives of Disease in Childhood
|September 28, 2014
PubMed

Insights

Standards for Research (StaR) in Child Health improves pediatric clinical trials. This global initiative develops evidence-based standards to enhance the reliability and relevance of research for children's health.

Area of Science:

  • Pediatric Clinical Research
  • Health Services Research

Background:

  • Significant growth in pediatric clinical research over the past decade.
  • Establishment of dedicated research infrastructure and support, such as the National Institute for Health Research in England, has facilitated more and better research by pediatricians.
  • Challenges remain in designing and conducting pediatric trials that significantly impact children's health outcomes.

Purpose of the Study:

  • To highlight the contributions of Standards for Research (StaR) in Child Health to improving pediatric clinical research.
  • To describe the international context of pediatric research standards development.
  • To suggest future integration of StaR's plans with existing research support mechanisms.

Main Methods:

  • Overview of the Standards for Research (StaR) in Child Health initiative.
  • Description of the global collaborative approach involving methodologists, clinicians, patient advocacy groups, and policymakers.
  • Analysis of the development of practical, evidence-based standards for pediatric clinical research.

Main Results:

  • Standards for Research (StaR) in Child Health was founded in 2009 to address the lack of and shortcomings in pediatric clinical trials.
  • The initiative focuses on developing standards to enhance the reliability and relevance of research for children's health.
  • StaR's work is situated within an international context of efforts to improve pediatric research.

Conclusions:

  • Standards for Research (StaR) in Child Health plays a crucial role in advancing pediatric clinical research.
  • The initiative's evidence-based standards aim to improve the quality and impact of research for children.
  • Future integration of StaR's plans with existing research support can further enhance pediatric health outcomes.

Keywords:
Evidence Based MedicineOutcomes research

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