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The relation between neutrophil-to-lymphocyte ratio and coronary chronic total occlusions

Kenan Demir1, Ahmet Avci, Bulent Behlul Altunkeser

  • 1Faculty of Medicine Cardiology Department, Selcuk University, 42075 Konya, Turkey. drkenan76@yahoo.com.

BMC Cardiovascular Disorders
|September 28, 2014
PubMed

Insights

The neutrophil-to-lymphocyte ratio (NLR) is elevated in patients with chronic total coronary occlusion (CTO). Higher NLR levels independently predict CTO presence, suggesting its utility as a diagnostic marker.

Area of Science:

  • Cardiology
  • Inflammation Markers

Background:

  • Neutrophil-to-lymphocyte ratio (NLR) indicates systemic inflammation and correlates with cardiac events.
  • The role of NLR in chronic total coronary occlusion (CTO) requires further investigation.

Purpose of the Study:

  • To assess the association between NLR and the presence of CTO.
  • To determine if NLR can serve as a predictive marker for CTO.

Main Methods:

  • A study involving 225 patients, divided into control, coronary artery disease, and CTO groups (n=75 each).
  • Comparison of NLR levels across the three patient groups.
  • Correlation and regression analyses to evaluate NLR's predictive value for CTO.

Main Results:

  • NLR levels were significantly higher in the CTO group compared to control and coronary artery disease groups (p < 0.001).
  • NLR showed a positive correlation with the SYNTAX Score.
  • NLR was identified as an independent predictor of CTO, with a cut-off of 2.09 providing moderate diagnostic accuracy (AUC = 0.74).

Conclusions:

  • NLR may serve as a valuable biomarker for identifying patients with CTO.
  • Elevated NLR levels are associated with the presence and severity of coronary artery disease, specifically CTO.
Abstract

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