Vagal baroreflex activation resulting in acute coronary stent thrombus associated with myocardial infarction: a case report
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Updated: Apr 23, 2026

Semi-Minimal Invasive Method to Induce Myocardial Infarction in Rats and the Assessment of Cardiac Function by an Isolated Working Heart System
Published on: June 11, 2020
Yan-Yan Jing, De-Cai Luan, Liu-Dong Li1
1Department of Cardiology, Yuhuangding Hospital, Qingdao Medical College, Qingdao University, Yantai, Shandong Province, China. winterlee@hotmail.com.
Insights
This case report highlights a rare complication of percutaneous coronary intervention: vagal baroreflex activation leading to stent thrombosis. Early recognition and intra-aortic balloon pump therapy are crucial for managing this adverse event.
Area of Science:
- Cardiology
- Interventional Cardiology
- Vascular Physiology
Background:
- Percutaneous coronary intervention (PCI) with stenting can impact baroreflex regulation of hemodynamics.
- Vagal baroreflex activation following PCI, especially leading to stent thrombosis, is not well-documented.
Background:
Percutaneous coronary intervention with stenting in patients with coronary atheromatous stenosis carry an inherent risk of affecting the baroreflex-mediated regulation of hemodynamic alterations, especially for heart rate and blood pressure. To the best of our knowledge, the vagal baroreflex activation associated with acute coronary stent thrombosis in patients who have undergone percutaneous coronary intervention has not been previously reported.
Case Presentation:
In the present article, we report a case of a Chinese patient (a 75-year-old male) with coronary artery disease who presented with hemodynamic alterations as a complication of vagal baroreflex activation after implantation of overlapping stents, followed by stent thrombosis associated with myocardial infarction.
Conclusion:
The patient's vagal baroreflex sensitivity increased after the coronary stenting procedure. He was successfully treated with intra-aortic balloon pump therapy. Because of its rarity, this case is being reported to emphasize the importance of using intra-aortic balloon pump therapy.
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