Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cerebral Edema ll: Pathophysiology

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this...

Cerebral Edema l: Introduction

Cerebral Edema l: Introduction

Cerebral edema is a pathological increase in brain water content that disrupts intracranial pressure regulation and impairs neurological function. Because the cranial vault is rigid, even modest increases in tissue volume can compromise cerebral perfusion, distort neural structures, and initiate secondary injury. Cerebral edema develops through four principal mechanisms: vasogenic, cytotoxic, interstitial, and ionic.Vasogenic EdemaVasogenic edema arises from disruption of the blood–brain...

Increased Intracranial Pressure ll: Pathophysiology

Increased Intracranial Pressure ll: Pathophysiology

Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins...

Brain Abscess l: Introduction

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial...

Increased Intracranial Pressure l: Introduction

Increased Intracranial Pressure l: Introduction

Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Multimodal EEG-fNIRS classification as a clinical tool for bipolar disorder diagnosis.

Translational psychiatry·2026

Same author

Anomalous Pressure Dependence of the Charge Density Wave and Fermi Surface Reconstruction in BaFe_{2}Al_{9}.

Physical review letters·2025

Same author

Rapid synthesis process and characterization for high purity sodium thioantimoniate nonahydrate.

Dalton transactions (Cambridge, England : 2003)·2022

Same author

Monthly anomaly database of atmospheric and oceanic parameters in the tropical Atlantic ocean.

Data in brief·2022

Same author

Omasal flow of nonstructural carbohydrates and nitrogenous compounds in lactating dairy cows fed diets containing timothy cut in the afternoon or morning.

Journal of dairy science·2021

Same author

A case of extreme hydrocephalus in a 67-year-old man whose professional and social lives were normal.

Neuro-Chirurgie·2021

Search research articles

Related Experiment Video

Updated: Apr 23, 2026

Author Spotlight: A Single-Entry Point Endoscopic Intraventricular Approach for Third Ventriculostomy and Pineal Biopsy

Author Spotlight: A Single-Entry Point Endoscopic Intraventricular Approach for Third Ventriculostomy and Pineal Biopsy

Published on: June 28, 2024

Cerebral tumor or pseudotumor?

D Leclercq¹, S Trunet¹, A Bertrand¹

¹Neuroradiology Department, Pitié-Salpêtrière Hospital, 47-83, boulevard de l'Hôpital, 75013 Paris, France.

Diagnostic and Interventional Imaging

|September 28, 2014

Summary

Identifying pseudotumoral lesions is crucial, as they mimic tumors in inflammatory, infectious, or vascular conditions. MRI findings, clinical context, and biology are key to differentiating these from actual tumor progression.

Keywords:

Behçet Brain Histiocytosis Sarcoidosis Tumour

More Related Videos

Translational Orthotopic Models of Glioblastoma Multiforme

Translational Orthotopic Models of Glioblastoma Multiforme

Published on: February 17, 2023

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

Related Experiment Videos

Last Updated: Apr 23, 2026

Author Spotlight: A Single-Entry Point Endoscopic Intraventricular Approach for Third Ventriculostomy and Pineal Biopsy

Author Spotlight: A Single-Entry Point Endoscopic Intraventricular Approach for Third Ventriculostomy and Pineal Biopsy

Published on: June 28, 2024

Translational Orthotopic Models of Glioblastoma Multiforme

Translational Orthotopic Models of Glioblastoma Multiforme

Published on: February 17, 2023

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

Area of Science:

Neurology
Radiology
Oncology

Background:

Pseudotumoral lesions are rare but clinically significant, often mimicking neoplastic processes.
Differential diagnosis is challenging, especially in patients with treated tumors, where pseudo-progression and radionecrosis can be mistaken for tumor recurrence.
These lesions can arise from inflammatory, infectious, or vascular etiologies.

Purpose of the Study:

To highlight the diagnostic challenges of pseudotumoral lesions on MRI.
To outline imaging features that suggest a non-tumoral origin.
To emphasize the importance of integrating imaging findings with clinical and biological data.

Main Methods:

Review of MRI characteristics in conventional sequences, diffusion-weighted imaging (DWI), perfusion imaging, and magnetic resonance spectroscopy (MRS).
Correlation of imaging findings with clinical presentation, patient history, and laboratory results.
Analysis of lesion evolution under treatment or spontaneously.

Main Results:

Specific MRI features, such as T2 hyposignal, can suggest conditions like granulomatosis or histiocytosis, particularly with associated meningeal or hypothalamic-pituitary involvement.
Non-tumoral lesions typically exhibit reduced perfusion compared to neoplastic lesions.
The presence of other intracranial lesions can indicate systemic or infectious diseases.

Conclusions:

Accurate diagnosis of pseudotumoral lesions requires a multidisciplinary approach, integrating MRI findings with clinical context and biological data.
Certain MRI patterns can strongly suggest a pseudotumoral origin, aiding in differentiation from malignant tumors.
Monitoring lesion evolution is fundamental for diagnosis when definitive imaging criteria are absent.