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Manipulation of host pathways by human cytomegalovirus: insights from genome-wide studies

Yifat Cohen1, Noam Stern-Ginossar

  • 1Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 76100, Israel.

Seminars in Immunopathology
|September 28, 2014
PubMed

Insights

Human cytomegalovirus (HCMV) infects most people, causing illness in newborns and immunocompromised adults. This review covers new high-throughput findings on how HCMV manipulates host cells for its replication, offering therapeutic targets.

Area of Science:

  • Virology
  • Cell Biology
  • Immunology

Background:

  • Human cytomegalovirus (HCMV) is a widespread herpesvirus causing significant disease in vulnerable populations.
  • HCMV infection impacts millions of newborns and immunocompromised adults annually.
  • The virus extensively manipulates host cellular gene expression for its propagation.

Purpose of the Study:

  • To review recent high-throughput findings on HCMV infection.
  • To understand how HCMV subverts cellular pathways.
  • To identify potential therapeutic targets and novel cell biology principles.

Main Methods:

  • This review synthesizes data from recent high-throughput analyses.
  • The focus is on understanding viral manipulation of host gene expression.
  • The study integrates findings from various molecular and cellular biology approaches.

Main Results:

  • High-throughput analyses have significantly advanced the understanding of HCMV infection processes.
  • New insights reveal complex viral strategies for manipulating host cell machinery.
  • Identified pathways offer potential for novel therapeutic interventions.

Conclusions:

  • Recent advances provide a deeper understanding of HCMV's interaction with host cells.
  • Targeting virus-manipulated pathways holds promise for treating HCMV-related diseases.
  • Further research into HCMV-driven cellular changes can uncover fundamental biological mechanisms.

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