Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

1.4K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.4K
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

16
Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
16
Alterations in Muscle Tone lll01:11

Alterations in Muscle Tone lll

22
Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...
22
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

2.2K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.2K
Parkinson Disease l: Introduction01:24

Parkinson Disease l: Introduction

12
Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of...
12
Alterations in Muscle Tone ll01:12

Alterations in Muscle Tone ll

21
Alterations in muscle tone are common manifestations of neurological disorders and reflect dysfunction within different nervous system regions. Spasticity, paratonia, and dystonia represent distinct forms of hypertonia, each with unique mechanisms, clinical features, and diagnostic importance.CharacteristicsSpasticity happens from upper motor neuron lesions and is characterized by velocity-dependent resistance to passive movement. Clinical features include:Exaggerated deep tendon reflexesClonus...
21

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Explorative investigation on effects of multi-day neurofeedback with implanted electrodes in patients with Parkinson's disease.

Neuroscience·2026
Same author

ActiTect: a generalizable machine learning pipeline for REM sleep behavior disorder screening through standardized actigraphy.

NPJ digital medicine·2026
Same author

Enhancing sleep slow waves with auditory stimulation in people with Parkinson's disease: a randomized proof-of-concept trial.

Scientific reports·2026
Same author

Genetic associations between post-traumatic stress disorder and REM-sleep behavior disorder.

NPJ Parkinson's disease·2026
Same author

Wearable Movement-Tracking for Prodromal Parkinson's Disease Detection: A Cross-Country Validation Study.

Movement disorders : official journal of the Movement Disorder Society·2026
Same author

Auditory Stimulation of Slow-Wave Sleep Promotes Recovery after Brain Injury in an Animal Model.

Annals of neurology·2026
Same journal

Cerebellum crus II cortical thickness as a cognitive brain reserve in Parkinson's disease.

Parkinsonism & related disorders·2026
Same journal

Serious games and virtual reality in Parkinson's disease rehabilitation: A systematic review of randomized controlled trials.

Parkinsonism & related disorders·2026
Same journal

Respiratory-swallow training in Parkinson's disease: Effects of a single session on swallowing safety and efficiency with exploratory comparisons of biofeedback.

Parkinsonism & related disorders·2026
Same journal

Levodopa responsive childhood-onset generalized dystonia with diaphragmatic involvement associated with an SPTBN2 variant.

Parkinsonism & related disorders·2026
Same journal

Approach to a case of Neuro-Gonadal disorder: Perrault syndrome.

Parkinsonism & related disorders·2026
Same journal

Parakinesia in Chorea: Why attribution of intention is misleading.

Parkinsonism & related disorders·2026
See all related articles

Related Experiment Video

Updated: Apr 23, 2026

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
05:54

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor

Published on: December 13, 2017

13.7K

Dopamine-responsive pattern in tremor patients.

Lukas L Imbach1, Michael Sommerauer1, Kaspar Leuenberger2

  • 1Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, 8091 Zurich, Switzerland.

Parkinsonism & Related Disorders
|September 28, 2014
PubMed
Summary
This summary is machine-generated.

Accelerometry can predict levodopa (l-Dopa) response in tremor patients. Harmonic oscillations measured by accelerometry strongly correlate with clinical l-Dopa response, offering a non-invasive prediction method.

Keywords:
Quantitative tremor analysisTremorl-Dopa response

More Related Videos

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

13.6K
Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease
06:45

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease

Published on: October 4, 2021

3.2K

Related Experiment Videos

Last Updated: Apr 23, 2026

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
05:54

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor

Published on: December 13, 2017

13.7K
Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

13.6K
Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease
06:45

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease

Published on: October 4, 2021

3.2K

Area of Science:

  • Neurology
  • Biomedical Engineering
  • Medical Diagnostics

Background:

  • Tremor diagnosis and treatment rely on clinical assessment, but levodopa (l-Dopa) response varies significantly among patients.
  • Predicting l-Dopa response is crucial for effective tremor management.
  • Current methods lack precision in forecasting individual patient outcomes.

Purpose of the Study:

  • To investigate accelerometry as a tool for predicting levodopa (l-Dopa) response in tremor patients.
  • To establish a correlation between harmonic oscillations measured by accelerometry and clinical l-Dopa response.
  • To explore a novel, non-invasive method for assessing l-Dopa efficacy in tremor.

Main Methods:

  • Sixty tremor patients were enrolled in the study.
  • Harmonic oscillations were quantified using accelerometry.
  • Patients underwent neurological assessment and levodopa (l-Dopa) challenge tests, with tremor response compared to accelerometry data.

Main Results:

  • A significant correlation was observed between harmonic oscillations and clinical levodopa (l-Dopa) response.
  • Patients reporting subjective tremor reduction after l-Dopa administration exhibited greater harmonic oscillations.
  • Accelerometry effectively differentiated responders from non-responders to l-Dopa treatment.

Conclusions:

  • Harmonic oscillations measured by accelerometry serve as a reliable indicator of levodopa (l-Dopa) response in tremor, regardless of the underlying etiology.
  • This study proposes a novel, non-invasive approach for predicting l-Dopa response in tremor patients.
  • While causality is speculative due to the observational nature, accelerometry shows promise for personalized tremor treatment.