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[Coronary microvascular dysfunction and aortic stenosis: an update]

P Meimoun1, D Czitrom2

  • 1Service de cardiologie-USIC, centre hospitalier de Compiègne, 8, rue Henri-Adnot, 60200 Compiègne, France.

Annales De Cardiologie Et D'Angeiologie
|September 28, 2014
PubMed

Insights

Coronary microcirculatory impairment is central to aortic stenosis (AS) pathophysiology. This review explores its causes, links to heart changes, and its role in diagnosing and predicting AS outcomes.

Area of Science:

  • Cardiology
  • Vascular Biology
  • Cardiac Physiology

Context:

  • Aortic stenosis (AS) is a prevalent valvular heart disease requiring surgical intervention.
  • Coronary microcirculatory dysfunction is increasingly recognized in AS pathophysiology.
  • Existing research utilizes diverse methods to assess microcirculatory impairment in AS patients.

Purpose:

  • To review the multifaceted impairment of the coronary microcirculation in aortic stenosis.
  • To elucidate the origins and functional implications of this impairment.
  • To examine the relationship between microcirculatory function, left ventricular hypertrophy, and AS severity.

Summary:

  • Coronary microcirculatory impairment is a significant pathophysiological component of aortic stenosis.
  • Its origins are multifactorial, involving hemodynamic changes and left ventricular hypertrophy.
  • The review synthesizes current knowledge on diagnostic and prognostic implications.

Impact:

  • Highlights the importance of assessing coronary microcirculation in AS management.
  • Provides a comprehensive overview for clinicians and researchers.
  • Underscores potential avenues for improved diagnostic and therapeutic strategies in AS.

Keywords:
Aortic stenosisCoronary flow reserveMicrocirculationRéserve coronaireRétrécissement aortique

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