Enlight: web-based integration of GWAS results with biological annotations

Yunfei Guo1, David V Conti1, Kai Wang2

  • 1Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA 90033, Department of Preventive Medicine, USC Keck School of Medicine, Los Angeles, CA 90032 and Department of Psychiatry & Behavioral Sciences, USC Keck School of Medicine, Los Angeles, CA 90033, USA Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA 90033, Department of Preventive Medicine, USC Keck School of Medicine, Los Angeles, CA 90032 and Department of Psychiatry & Behavioral Sciences, USC Keck School of Medicine, Los Angeles, CA 90033, USA.

Summary

Enlight is a web tool that helps researchers interpret genome-wide association study (GWAS) results. It overlays functional data to identify causal single-nucleotide polymorphisms (SNPs) in non-coding regions.

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Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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