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Updated: Apr 23, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Postpartum depression and psycho-socio-demographic predictors
Fatemeh Abdollahi1, Shariff-Ghazali Sazlina, Azhar Md Zain
1Department of Public Health, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran.
Introduction:
There appears to be a growing international recognition of postpartum depression as a significant public health concern. This paper determined the prevalence and psycho-socio-demographic predictors of postpartum depression symptomatology and its constancy over 12-week postpartum in Mazandaran province Iranian women.
Methods:
Edinburgh Postnatal Depression Scale and General Health Questionnaire were used to identify possible health and depression status in a cohort of 1,950 eligible pregnant women who attended primary health centers from January to June 2010, at 2 and 12 weeks postpartum. Logistic regression analysis was used to determine the predictors of postpartum depression among women.
Results:
Prevalence of continued depression was found to be 9.9% on all three assessments. A mother's psychological distress, experience of depression, and anxiety in the first and second trimester of pregnancy and a family history of depression were the characteristics that had the strongest significant association with the development of postpartum depression. Women who married at a younger age also were more prone to postpartum depression development.
Conclusions:
One in ten depressed women in this study continued to be depressed over the 12-week postpartum period. Interventions should target women with the greatest risk, especially those with psychological distress during pregnancy.
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