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Related Concept Videos

Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

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Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
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Spinal Cord Injury ll: Pathophysiology01:14

Spinal Cord Injury ll: Pathophysiology

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Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
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Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

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A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
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Ischemic Stroke ll: Pathophysiology01:15

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An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
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Related Experiment Video

Updated: Apr 23, 2026

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke
08:01

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Interlimb neural coupling: implications for poststroke hemiparesis.

K N Arya1, S Pandian1

  • 1Pt. Deendayal Upadhyaya Institute for the Physically Handicapped (University of Delhi), Ministry of Social Justice & Empowerment, Government of India, New Delhi 110002, India.

Annals of Physical and Rehabilitation Medicine
|September 30, 2014
PubMed
Summary
This summary is machine-generated.

Interlimb coordination relies on neural coupling for movement. Stroke rehabilitation can improve motor function by incorporating bilateral limb movements, challenging traditional methods.

Keywords:
Bimanual taskCommunication inter-hémisphériqueCoordination inter-membresCouplage neuronalCoupled movementInterhemispheric communicationInterlimb coordinationMouvement coupléNeural couplingRééducation après AVCStroke rehabilitationTâche bimanuelle

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Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke
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Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke
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Area of Science:

  • Neuroscience
  • Motor Control
  • Rehabilitation Science

Background:

  • Interlimb coordination is vital for daily tasks and locomotion, involving spatiotemporal coupling of movements.
  • Neural coupling, through spinal and brain linkages, underlies coordinated movements between limbs.
  • Central pattern generators and interhemispheric interactions are key neural mechanisms for rhythmic and bimanual movements.

Purpose of the Study:

  • To review the mechanisms of interlimb coordination and neural coupling.
  • To explore the implications of neural coupling in stroke rehabilitation.

Main Methods:

  • This review synthesizes existing literature on interlimb coordination, neural coupling, and stroke.
  • It examines neuroanatomical and neurophysiological evidence supporting these concepts.

Main Results:

  • Neural coupling facilitates coordinated movements across upper and lower limbs, influenced by task demands.
  • Stroke often results in bimanual motor impairments, including asymmetry and reduced coordination.
  • Upper limb movement can enhance lower limb neuromuscular activity.

Conclusions:

  • Stroke rehabilitation strategies should consider incorporating simultaneous or consecutive bilateral limb movements for hemiparetic individuals.
  • Conventional and contemporary rehabilitation approaches may need reevaluation to leverage neural coupling principles.