Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effectiveness and Safety of Early Rhythm Control in Patients With Atrial Fibrillation and Chronic Kidney Disease.

Journal of the American College of Cardiology·2026
Same author

Transforming atrial fibrillation management by targeting comorbidities and reducing atrial fibrillation burden: the 10th AFNET/EHRA consensus conference.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2025
Same author

Prevalence and severity of atrial cardiomyopathy in patients with recently diagnosed atrial fibrillation and stroke risk factors and its association with early rhythm control: a secondary analysis of EAST-AFNET 4.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2025
Same author

Safety and efficacy of amiodarone and dronedarone for early rhythm control in EAST-AFNET 4.

Clinical research in cardiology : official journal of the German Cardiac Society·2025
Same author

Apixaban, edoxaban and rivaroxaban but not dabigatran are associated with higher mortality compared to vitamin-K antagonists: A retrospective German claims data analysis.

Journal of internal medicine·2024
Same author

Biomarker-based prediction of sinus rhythm in atrial fibrillation patients: the EAST-AFNET 4 biomolecule study.

European heart journal·2024

Related Experiment Video

Updated: Apr 23, 2026

Confirmation of Myocardial Ischemia and Reperfusion Injury in Mice Using Surface Pad Electrocardiography
09:23

Confirmation of Myocardial Ischemia and Reperfusion Injury in Mice Using Surface Pad Electrocardiography

Published on: November 24, 2016

13.0K

Negative T wave in ischemic heart disease: a consensus article.

Antonio Bayés de Luna1, Wojciech Zareba, Miquel Fiol

  • 1Santa Creu i Sant Pau Hospital, Cardiovascular Research Center, CSIC-ICCC, Barcelona, Spain.

Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
|September 30, 2014
PubMed
Summary

Negative T waves in ischemic heart disease do not indicate acute ischemia but rather vanishing or chronic phases. These patterns, often originating from subepicardial areas, appear during reperfusion or post-myocardial infarction.

Keywords:
electrocardiographyischemic heart diseasenegative T wave

More Related Videos

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
18:11

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

Published on: December 28, 2012

23.8K
Model of Ischemia and Reperfusion Injury in Rabbits
06:11

Model of Ischemia and Reperfusion Injury in Rabbits

Published on: November 3, 2023

2.0K

Related Experiment Videos

Last Updated: Apr 23, 2026

Confirmation of Myocardial Ischemia and Reperfusion Injury in Mice Using Surface Pad Electrocardiography
09:23

Confirmation of Myocardial Ischemia and Reperfusion Injury in Mice Using Surface Pad Electrocardiography

Published on: November 24, 2016

13.0K
A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
18:11

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

Published on: December 28, 2012

23.8K
Model of Ischemia and Reperfusion Injury in Rabbits
06:11

Model of Ischemia and Reperfusion Injury in Rabbits

Published on: November 3, 2023

2.0K

Area of Science:

  • Cardiology
  • Electrocardiography
  • Ischemic Heart Disease

Background:

  • Historically, negative T waves in ischemic heart disease were attributed to ischemia and subepicardial localization.
  • This traditional view is re-examined based on current understanding and clinical observations.

Purpose of the Study:

  • To clarify the true significance of negative T waves in patients with ischemic heart disease.
  • To differentiate between primary and secondary causes of negative T waves.

Main Methods:

  • A comprehensive literature review was conducted.
  • Author expertise and clinical experience were integrated into the analysis.

Main Results:

  • Negative T waves can be primary or secondary; those in ischemic heart disease are typically primary.
  • Ischemic negative T waves exhibit symmetry, variable depth, mirror patterns, and may involve U waves.
  • These patterns are observed post-myocardial infarction (window effect) and during reperfusion (spontaneous or intervention-induced).

Conclusions:

  • Acute, ongoing ischemia does not cause negative T waves; they appear during resolution or in chronic phases.
  • The origin of ischemic negative T waves is not subepicardial.
  • Negative T waves can occur in non-ischemic conditions, warranting careful differential diagnosis.