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Hepatitis C virus infection increases the risk of developing peripheral arterial disease: a 9-year population-based

Yueh-Han Hsu1, Chih-Hsin Muo2, Chun-Yi Liu3

  • 1Department of Public Health, China Medical University, Taichung City 404, Taiwan; Department of Health Services Administration, China Medical University, Taichung City 404, Taiwan; Department of Internal Medicine, Division of Nephrology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi City 600, Taiwan; Department of Nursing, Min-Hwei Junior College of Health Care Management, Tainan City 736, Taiwan.

Journal of Hepatology
|September 30, 2014
PubMed

Insights

Hepatitis C virus (HCV) infection significantly increases the risk of developing peripheral arterial disease (PAD). This risk is higher in HCV patients with comorbidities and increases with age.

Area of Science:

  • Vascular Medicine
  • Hepatology
  • Epidemiology

Background:

  • The association between hepatitis C virus (HCV) infection and peripheral arterial disease (PAD) requires further elucidation.
  • HCV is a global health concern with potential systemic implications.

Purpose of the Study:

  • To investigate the independent risk of developing PAD in patients with HCV infection.
  • To identify factors modifying the risk of PAD in the context of HCV.

Main Methods:

  • A retrospective cohort study utilizing health insurance claims data from 1998-2011.
  • 7,641 HCV-infected patients were matched with 30,564 controls, excluding those with prior hepatitis B or PAD.
  • Multivariate Cox hazard models were employed to assess the adjusted risk of PAD development.

Main Results:

  • HCV-infected patients demonstrated a 1.43-fold increased risk of developing PAD compared to controls.
  • PAD risk escalated with age, with significantly higher risks observed in older HCV patients.
  • Chronic kidney disease/end-stage renal disease and multiple comorbidities substantially elevated PAD risk in HCV patients.

Conclusions:

  • HCV infection is an independent risk factor for developing PAD.
  • Comorbidities amplify the risk of PAD in HCV-infected individuals, highlighting the need for comprehensive patient management.
Abstract

Keywords:
Cardiovascular diseaseChronic kidney diseaseComorbidityHepatitisPeripheral arterial diseaseStroke

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