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Suture cartilage formation pattern varies with different expansive forces.

Yang Liu1, Yi Tang2, Ling Xiao2

  • 1Assistant professor, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.

American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics
|September 30, 2014
PubMed
Summary
This summary is machine-generated.

Lower magnitude midpalatal suture expansion (10g) promotes chondrocyte proliferation, offering a preferable cartilage response. Higher expansion (20g) primarily increases cartilage matrix production.

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Area of Science:

  • Orthodontics
  • Craniofacial development
  • Tissue engineering

Background:

  • Midpalatal suture expansion can correct maxillary insufficiency by inducing osteogenesis.
  • Cartilage formation is also a potential outcome of expansion.
  • Lower forces may yield a more favorable response pattern.

Purpose of the Study:

  • To investigate the cartilage formatting effects of varying expansion forces on the midpalatal suture.
  • To compare the cellular and matrix responses to different expansion magnitudes.

Main Methods:

  • Thirty mice underwent sustained suture expansion at 0g (control), 10g, or 20g for 7 days.
  • Histological analysis included toluidine blue and safranin-O staining.
  • Immunohistochemistry assessed proliferating cell nuclear antigen (PCNA), Ki-67, alkaline phosphatase (ALP), and matrix metalloproteinase 13 (MMP-13) expression.

Main Results:

  • 20g expansion significantly increased cartilage matrix volume and hypertrophic chondrocytes, with elevated MMP-13 expression.
  • 10g expansion led to condensed proliferating chondrocyte masses with higher PCNA and Ki-67 positive cells.
  • Both 10g and 20g expansions increased ALP expression.

Conclusions:

  • 10g expansion promoted chondrocyte proliferation, indicating a more favorable suture cartilage response.
  • 20g expansion predominantly enhanced cartilage matrix production.
  • Optimal expansion force is crucial for directing specific cellular responses in suture expansion.