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Quantification of Optic Nerve Cross Sectional Area on MRI: A Novel Protocol using Fiji Software

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Improved diffusion tensor imaging of the optic nerve using multishot two-dimensional navigated acquisitions.

Ha-Kyu Jeong^1,2, Blake E Dewey^3,4, Jane A T Hirtle^3,5

¹Philips Healthcare Korea, Seoul, Republic of Korea.

Magnetic Resonance in Medicine

|September 30, 2014

Summary

This summary is machine-generated.

A novel multishot diffusion-weighted imaging technique offers improved optic nerve imaging with reduced artifacts and better reproducibility compared to single-shot methods, aiding in the assessment of optic nerve pathology.

Keywords:

2D navigator DTI multishot optic nerve

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Area of Science:

Neuroimaging
Medical Physics
Ophthalmology

Background:

Conventional single-shot echo-planar imaging (EPI) for optic nerve imaging is prone to artifacts and motion-related variability.
High-resolution imaging of the optic nerve is crucial for diagnosing and monitoring various pathologies.

Purpose of the Study:

To investigate a diffusion-weighted multishot EPI technique with SENSE and 2D navigated motion correction as an alternative to single-shot EPI for optic nerve imaging.
To evaluate the potential for higher spatial resolution and reduced artifacts in optic nerve imaging using the multishot approach.

Main Methods:

Fifteen healthy subjects underwent both single-shot and multishot diffusion tensor imaging (DTI) of the optic nerve with matched scan times.
Two-dimensional (2D) navigated motion correction was applied during multishot image reconstruction.
Tensor-derived indices, image resolution, optic nerve asymmetry, and test-retest reproducibility were compared between the two methods.

Main Results:

Multishot EPI demonstrated significantly reduced image artifacts (distortions, blurring) compared to single-shot EPI.
Diffusion indices derived from multishot scans were comparable to existing literature values.
Multishot scans showed less variability in optic nerve asymmetry and test-retest measurements than single-shot scans.

Conclusions:

The investigated multishot diffusion-weighted imaging technique provides improved optic nerve imaging with enhanced resolution and reduced artifacts.
This technique shows potential for better assessment of optic nerve pathology and may be adaptable to higher magnetic field strengths.