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Vertebral artery dissection in patients with autosomal dominant polycystic kidney disease

Takuma Kuroki1, Kazuo Yamashiro1, Ryota Tanaka1

  • 1Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|September 30, 2014
PubMed

Insights

Autosomal dominant polycystic kidney disease (ADPKD) can lead to rare arterial dissections, including in the vertebral artery. This finding suggests ADPKD may be a contributing factor in arterial dissection cases.

Area of Science:

  • Nephrology
  • Neurology
  • Vascular Medicine

Background:

  • Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disorder.
  • ADPKD is linked to various extrarenal complications, including vascular issues like intracranial aneurysms and aortic aneurysms.

Observation:

  • Intracranial arterial dissection is a rare complication of ADPKD.
  • Two cases of ADPKD patients with vertebral artery (VA) dissection are presented.
  • One patient experienced dissection in the contralateral VA and internal carotid artery.

Findings:

  • Both patients had a history of hypertension, common in ADPKD.
  • Serum creatinine levels were normal in both patients, indicating preserved kidney function.
  • The cases highlight a potential association between ADPKD and arterial dissection.

Implications:

  • ADPKD should be considered a potential risk factor for arterial dissection.
  • Further research is needed to understand the pathogenic mechanisms linking ADPKD and arterial dissection.
  • This may lead to improved screening and management strategies for ADPKD patients at risk of vascular complications.

Keywords:
Autosomal dominant polycystic kidney diseasecerebral angiographyhypertensionvertebral artery dissection

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