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Non-Canonical Wnt Signaling Pathways

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

Canonical Wnt Signaling Pathway

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...

Canonical Wnt Signaling Pathway

Canonical Wnt Signaling Pathway

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Related Experiment Video

Updated: Apr 23, 2026

Large-scale Gene Knockdown in C. elegans Using dsRNA Feeding Libraries to Generate Robust Loss-of-function Phenotypes

Large-scale Gene Knockdown in C. elegans Using dsRNA Feeding Libraries to Generate Robust Loss-of-function Phenotypes

Published on: September 25, 2013

Wnt signaling in C. elegans.

Hitoshi Sawa¹, Hendrik C Korswagen

¹Multicellular Organization Laboratory, National Institute of Genetics, 1111 Yata, Mishima, 411-8540 Japan.

Wormbook : the Online Review of C. Elegans Biology

|September 30, 2014

Summary

Wnt proteins, essential for development across species, regulate key processes in C. elegans. This review overviews Wnt signaling mechanisms controlling cell fate, division, migration, and synapse formation.

Area of Science:

Developmental Biology
Molecular Biology
Cell Biology

Background:

Wnt proteins are secreted, lipid-modified glycoproteins crucial for organismal development.
They play significant roles in diverse developmental processes, including cell fate specification, asymmetric cell division, cell migration, and synapse formation.
Wnt signaling is conserved from sponges to vertebrates, highlighting its fundamental importance.

Purpose of the Study:

To provide a comprehensive overview of Wnt protein functions in Caenorhabditis elegans development.
To elucidate the signaling mechanisms underlying the diverse roles of Wnt proteins.
To synthesize current knowledge on Wnt-mediated developmental processes.

Main Methods:

Literature review of existing research on Wnt proteins and their signaling pathways.

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Last Updated: Apr 23, 2026

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Analysis of studies focusing on Wnt functions in C. elegans.

Synthesis of information on molecular mechanisms of Wnt signaling.

Main Results:

Wnt proteins regulate fundamental aspects of C. elegans development.
Specific signaling pathways mediate distinct Wnt functions, such as cell fate determination and migration.
Understanding these mechanisms is key to comprehending developmental processes.

Conclusions:

Wnt signaling is a critical pathway governing numerous developmental events in C. elegans.
Further research into Wnt signaling mechanisms will enhance our understanding of developmental biology.
The conserved nature of Wnt proteins underscores their importance in evolutionary developmental biology.