Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunologic tolerance: collaboration between antigen and lymphokines.

G J Nossal1

  • 1Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia.

Science (New York, N.Y.)
|July 14, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clonal deletion in self-tolerance.

Immunology today·2014
Same author

The case history of Mr T.I. Terminal patient or still curable?

Immunology today·2014
Same author

A purgative mastery.

Nature·2001
Same author

The Global Alliance for Vaccines and Immunization--a millennial challenge.

Nature immunology·2001
Same author

The new biology and human reproduction.

The Australian & New Zealand journal of obstetrics & gynaecology·2001
Same author

Modern medicine and global communicable diseases: new partnerships for progress.

Australian and New Zealand journal of medicine·2000

Self-tolerance, a key immune process, isn't a single event but a complex system. It involves multiple complementary mechanisms and feedback loops for regulating lymphocyte responses to the body's own antigens.

Area of Science:

  • Immunology
  • Immunoregulation

Background:

  • Immunologic tolerance limits lymphocyte responses to inherent antigens.
  • It's a quantitative, not absolute, process with common autoantibody formation.

Purpose of the Study:

  • To clarify the mechanisms underlying self-tolerance.
  • To understand self-tolerance beyond early developmental stages.

Main Methods:

  • Review of existing literature on immune system regulation.
  • Analysis of complementary mechanisms and feedback loops.

Main Results:

  • Self-tolerance is not a single, simple mechanism.
  • It arises from diverse, complementary processes within the immune system.

Related Experiment Videos

Conclusions:

  • Self-tolerance is a dynamic, multifaceted aspect of immunoregulation.
  • It involves continuous feedback and multiple control points, not just early development.