Two new xanthones from Lomatogonium carinthiacum

Area of Science:

• Phytochemistry
• Natural Product Chemistry
• Organic Chemistry

Background:

• Lomatogonium carinthiacum is a plant species with potential medicinal properties.
• Understanding its chemical constituents is crucial for pharmacological research and potential applications.

Purpose of the Study:

• To isolate and characterize novel chemical compounds from Lomatogonium carinthiacum.
• To contribute to the knowledge of xanthone derivatives in medicinal plants.

Main Methods:

• Extraction of the CHCl3-soluble fraction from the whole plant.
• Separation of compounds using various chromatographic techniques.
• Structure elucidation of isolated compounds via comprehensive spectral experiments (e.g., NMR, MS).

Main Results:

• Isolation of two new xanthone derivatives: 1,8-dihydroxy-4,5-dimethoxy-6,7-methylenedioxyxanthone (1) and 1,4,8-trimethoxyxanthone-6-O-β-D-glucoronyl-(1→6)O-β-D-glucoside (2).
• Confirmation of the novel structures through detailed spectral data analysis.

Conclusions:

• Compounds 1 and 2 represent new natural products.
• This study expands the known phytochemical profile of Lomatogonium carinthiacum.