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Updated: Apr 23, 2026
Author Spotlight: Developing a Rat Model for Pouchitis Research and Treatment
Published on: May 31, 2024
Faecal matrix metalloprotease-9 is a more sensitive marker for diagnosing pouchitis than faecal calprotectin: results
Klaudia Farkas1, Anita Bálint, Renáta Bor
1First Department of Medicine, University of Szeged H-6720, Korányi fasor 8, Szeged, Hungary.
Background:
Potential non-invasive markers of pouchitis would have a great deal of significance within clinical practice.
Aim:
This study is aimed at assessing the diagnostic accuracy of fecal calprotectin and matrix metalloprotease-9 as potential markers in patients both with and without pouchitis.
Patients And Methods:
Stool and blood samples were collected from 33 ileal pouch-anal anastomosis patients before a follow-up pouchoscopy. Biopsy samples were taken for histological purposes. The presence of cuffitis and stenosis was evaluated with an endoscopy. Calprotectin and matrix metalloprotease-9 were quantified with an enzyme-linked immunosorbent assay.
Results:
Pouchitis was detected in 30.3% of the patients. The levels of fecal calprotectin and matrix metalloprotease-9 increased significantly in patients with pouchitis. The sensitivity and specificity of matrix metalloprotease-9 was higher than that of fecal calprotectin. Only matrix metalloprotease-9 correlated significantly with the severity of pouchitis.
Discussion:
Fecal matrix metalloprotease-9 has a high specificity in the diagnosis of pouchitis.
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