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Using response variation to develop more effective, personalized behavioral medicine?: evidence from the Resist
Richard A Winett1, Brenda M Davy2, Jyoti Savla3
1Psychology Department, Virginia Tech, Blacksburg, VA 24061 USA.
Translational Behavioral Medicine
|September 30, 2014
Summary
Health interventions show varied responses. Tailoring treatments to individual results, like in the Resist Diabetes study, may improve outcomes for prediabetes patients.
Area of Science:
- Behavioral medicine
- Exercise physiology
- Metabolic health
Background:
- Health behavior interventions often yield varied individual results.
- Focusing on average changes overlooks significant response variations in participants.
- Resistance training protocols show diverse effects on health markers.
Purpose of the Study:
- To analyze individual response variations to a resistance training protocol in adults with prediabetes.
- To explore the potential of personalized behavioral medicine for optimizing intervention outcomes.
- To investigate how to systematically translate adaptive intervention approaches into practice.
Main Methods:
- Study included 159 adults (ages 50-69) with prediabetes, overweight/obesity, and inactivity.
- A highly supervised resistance training protocol was administered with high adherence.
- Key outcomes measured included 2-hour oral glucose tolerance test (OGTT), lean/fat mass, strength, and blood pressure.
Main Results:
- Observed wide variations in response to the resistance training protocol.
- Individual changes in OGTT, body composition, strength, and blood pressure were highly variable.
- These findings are consistent with typical response patterns in exercise interventions.
Conclusions:
- Intervention success can be enhanced by addressing individual response variations.
- A personalized behavioral medicine approach could tailor interventions for better clinical outcomes.
- Systematic translation of adaptive interventions is crucial for improving public health.
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