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Prostaglandin A and J: antitumor and antiviral prostaglandins
M Fukushima1, T Kato, S Narumiya
1Aichi Cancer Center, Nagoya, Japan.
Advances in Prostaglandin, Thromboxane, and Leukotriene Research
|January 1, 1989
Abstract:
Prostaglandin(PG)s of the A and J series are categorized as antitumor, antiviral PGs. They have a reactive alpha, beta-unsaturated carbonyl in the cyclopentenone ring, which could be the active moiety. They are actively incorporated into cells and in part transferred to the nuclei, and lead to cell cycle arrest at G1 or cell death depending on the dose.