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Updated: Apr 23, 2026

Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies
Published on: January 7, 2019
HIV-2 X4 tropism is associated with lower CD4+ cell count in treatment-experienced patients
Benoit Visseaux1, Charlotte Charpentier, Caroline Rouard
1aINSERM, IAME, UMR 1137 bUniversité Paris Diderot, IAME, UMR 1137, Sorbonne Paris Cité cAP-HP, Hôpital Bichat, Laboratoire de Virologie, Paris dUniversité Bordeaux eINSERM, ISPED, Centre INSERM U897- Epidemiologie-Biostatistique, Bordeaux fAP-HP, Hôpital Bichat, Service de Maladies Infectieuses et Tropicales gAP-HP, Hôpital de la Pitié-Salpétrière, Service de Maladies Infectieuses et Tropicales, Paris, France.
Abstract:
The distribution and evolution of X4/R5 viral tropism during HIV-2 infection remains unknown. HIV-2 tropism was assessed in 83 antiretroviral-experienced patients with virological failure. Tropism was predicted as X4 in 58% of patients and was associated with a CD4 cell count of less than 100 cells/μl, and with a higher number of drug resistance mutations. This high prevalence of X4 virus might compromise the use of CCR5 inhibitors, currently mostly considered in HIV-2 salvage therapy of highly pretreated patients.
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