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Updated: Apr 23, 2026

Fabrication of Amyloid-β-Secreting Alginate Microbeads for Use in Modelling Alzheimer's Disease
Published on: July 6, 2019
Mesangial cells as amyloid factory: a unique contribution of animal models
Christophe Sirac1, Frank Bridoux2
11] University of Limoges, CNRS UMR 7276, Immunology, Limoges, France [2] National Reference Center for AL Amyloidosis and Other Monoclonal Immunoglobulin Deposition Diseases, Limoges, Poitiers, France.
Abstract:
AL amyloidosis is a severe complication of plasma-cell disorders, secondary to monoclonal immunoglobulin light chain (LC) deposition in the kidney and other organs. Though the physicochemical properties of amyloid-forming monoclonal LCs have been demonstrated to be involved in their propensity to aggregate, it remains unclear where, when, and finally why amyloid fibrils are formed in vivo. Teng et al. shed light on this long-standing issue thanks to a new animal model.
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Amyloid Fibrils
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Amyloid Fibrils