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Elevated concentrations of circulating cytokines and correlations with nerve conduction velocity in human peripheral

David J Allison¹, Lara A Green¹, David A Gabriel¹

¹Department of Kinesiology, Brock University, St. Catharines, Ontario L2S 3A1, Canada.

Journal of Neuroimmunology

|October 1, 2014

Abstract:

The purpose of the current study was to quantify the potential relationship between various cytokines and peripheral nerve function in humans, in-vivo. Measures of nerve conduction velocity (NCV) were examined prior to and following the induction of a cytokine spike. A significant negative correlation was found between the change in IL-1ra and the change in NCV at 24h post-exercise (r=-0.65, p=0.02) while a significant positive correlation was found between the change in IL-6 and the change in NCV at 2h post-exercise (r=0.61, p=0.048). It may be possible that different cytokines induce a unique neural influence at elevated concentrations.

Keywords:

Channelopathy Interleukin-10 Interleukin-1ra Interleukin-6 Nerve conduction velocity Tumor necrosis factor-alpha

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