Statistical analyses of protein folding rates from the view of quantum transition

Understanding protein folding rate is the primary key to unlock the fundamental physics underlying protein structure and its folding mechanism. Especially, the temperature dependence of the folding rate remains unsolved in the literature. Starting from the assumption that protein folding is an event of quantum transition between molecular conformations, we calculated the folding rate for all two-state proteins in a database and studied their temperature dependencies. The non-Arrhenius temperature relation for 16 proteins, whose experimental data had previously been available, was successfully interpreted by comparing the Arrhenius plot with the first-principle calculation. A statistical formula for the prediction of two-state protein folding rate was proposed based on quantum folding theory. The statistical comparisons of the folding rates for 65 two-state proteins were carried out, and the theoretical vs. experimental correlation coefficient was 0.73. Moreover, the maximum and the minimum folding rates given by the theory were consistent with the experimental results.