Urinary proteomics in obstructive sleep apnoea and obesity

Area of Science:

• Urology
• Metabolomics
• Sleep Medicine

Background:

• Obstructive sleep apnoea (OSA) is a common obesity complication impacting quality of life and cardiovascular risk.
• This study investigated urinary peptide profiles in obese subjects with and without OSA.

Purpose of the Study:

• To perform discovery profiling of urinary peptides using CE-MS in obese subjects with and without OSA.
• To identify potential biomarkers for OSA in obese individuals.

Main Methods:

• Urinary samples were analyzed using capillary electrophoresis-mass spectrometry (CE-MS).
• Body composition, blood pressure, and polysomnography data were collected.
• Participants with OSA were treatment-naïve.

Main Results:

• Sixty-one obese subjects with OSA and 31 controls without OSA were studied.
• Obese subjects with OSA showed a higher Apnoea-hypopnoea Index and prevalence of metabolic syndrome.
• Twenty-four candidate polypeptides showed differential distribution, with eight sequences identified from collagens and fibrinogen alpha.

Conclusions:

• This is the first study to report urinary proteomic profiles using CE-MS in obese OSA and non-OSA groups.
• Urinary proteomic profile differences suggest a potential role for CE-MS in characterizing obese populations with OSA.
• Further research may elucidate the role of identified peptides in OSA pathophysiology.