Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dupilumab versus placebo in adults and adolescents with eosinophilic gastritis (DEGAS): a double-blind, placebo-controlled, phase 2, multicentre, randomised controlled trial.

The lancet. Gastroenterology & hepatology·2026
Same author

Patient-Reported Outcome Scores Are Comparable in Multiregional Versus Uniregional Eosinophilic Esophagitis.

Gastro hep advances·2025
Same author

What Are Ethical Merits and Drawbacks of a Patient's Open and Direct Access to Clinical Information in Their EHRs During a Hospital Stay?

AMA journal of ethics·2025
Same author

Reply.

Gastroenterology·2025
Same author

Secondary review of extramural hematopathology cases for patients referred to an academic center: The increasing importance of subspecialized hematopathology practice.

American journal of clinical pathology·2025
Same author

Inflammatory Markers in Gastric Fluids Differentiate Patients With Eosinophilic Gastritis: Search for a Disease Screener.

Clinical and translational gastroenterology·2025

Related Experiment Video

Updated: Apr 23, 2026

Enhancing Tumor Content through Tumor Macrodissection
10:04

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

14.2K

Anaplastic large cell lymphoma: features presenting diagnostic challenges.

Maria A Pletneva1, Lauren B Smith

  • 1From the Department of Pathology, University of Michigan, Ann Arbor.

Archives of Pathology & Laboratory Medicine
|October 1, 2014
PubMed
Summary

Anaplastic large cell lymphoma (ALCL) diagnosis is complex, requiring careful consideration of various mimics like carcinoma and melanoma. Unusual morphologic and immunohistochemical findings present diagnostic challenges in practice.

More Related Videos

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
07:52

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma

Published on: January 9, 2019

19.7K
From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
10:18

From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia

Published on: October 19, 2014

13.2K

Related Experiment Videos

Last Updated: Apr 23, 2026

Enhancing Tumor Content through Tumor Macrodissection
10:04

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

14.2K
Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
07:52

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma

Published on: January 9, 2019

19.7K
From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
10:18

From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia

Published on: October 19, 2014

13.2K

Area of Science:

  • Oncology
  • Pathology
  • Hematology

Background:

  • Anaplastic large cell lymphoma (ALCL) presents diverse histopathologic features.
  • Accurate diagnosis requires distinguishing ALCL from a wide range of differential diagnoses.

Purpose of the Study:

  • To highlight the diagnostic complexities of anaplastic large cell lymphoma.
  • To present unusual morphologic and immunohistochemical findings encountered in ALCL cases.

Main Methods:

  • Review of histopathologic features of ALCL.
  • Analysis of immunohistochemical markers in challenging cases.
  • Presentation of variant patterns of anaplastic lymphoma kinase (ALK) expression.

Main Results:

  • Differential diagnosis includes carcinoma, melanoma, and various hematopoietic malignancies.
  • Unusual features such as histiocytic morphology and aberrant marker expression (cytokeratin, CD15) can complicate diagnosis.
  • Variant ALK expression patterns add to diagnostic complexity.

Conclusions:

  • The broad differential diagnosis for ALCL necessitates careful evaluation.
  • Awareness of unusual morphologic and immunohistochemical findings is crucial for accurate ALCL diagnosis.
  • Complex cases underscore the importance of integrated diagnostic approaches.