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Furosemide-induced eruption simulating Sweet's syndrome.

¹Department of Dermatology, Naval Hospital, Bethesda, MD 20814.

Journal of the American Academy of Dermatology

|August 1, 1989

Summary

An elderly man experienced a rash mimicking Sweet's syndrome after starting furosemide. The condition resolved upon medication withdrawal, indicating a drug eruption rather than Sweet's syndrome.

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Area of Science:

Dermatology
Pharmacology
Pathology

Background:

Sweet's syndrome is an acute febrile neutrophilic dermatosis.
Drug eruptions can present with diverse clinical and histological features.
Furosemide is a commonly prescribed diuretic with known potential adverse effects.

Observation:

An 88-year-old male developed a skin eruption 6 weeks into furosemide therapy.
The eruption clinically and histologically resembled Sweet's syndrome.
The patient's lesions resolved rapidly after discontinuing furosemide.

Findings:

The clinical presentation and rapid resolution upon drug withdrawal strongly suggested a furosemide-induced drug eruption.
Atypical features for Sweet's syndrome were noted in this case.
This report includes a review of known adverse cutaneous reactions to furosemide.

Implications:

Furosemide can induce drug eruptions that mimic other dermatological conditions like Sweet's syndrome.
Clinicians should consider drug-induced reactions in the differential diagnosis of patients presenting with Sweet's-like eruptions, especially after initiating new medications.
Awareness of furosemide's potential dermatological side effects is crucial for patient management.

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