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Updated: Apr 23, 2026

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
Published on: April 21, 2015
On naivety of T cells in inflammatory bowel disease: a review
Carolijn Smids1, Carmen S Horjus Talabur Horje, Peter J Wahab
1*Department of Gastroenterology and Hepatology, Rijnstate Hospital, Arnhem, the Netherlands; †Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands; and ‡Department of Microbiology and Immunology, Rijnstate Hospital, Arnhem, the Netherlands.
Abstract:
: Little is known about different phases of T-cell maturation in gut mucosa. Based on current knowledge about the migratory pathways of naive and memory T cells, it is believed that access to peripheral, nonlymphoid tissues is restricted to memory T cells. Surprisingly, there is increasing evidence of high numbers of naive T cells in the chronically inflamed gut tissue of patients with inflammatory bowel disease. This could partially be explained by new formation of ectopic lymphoid organs. Ongoing recruitment of naive T cells at inflammatory sites might play a role in the immunopathogenesis of inflammatory bowel disease.
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