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Georgios Pantouris1, Deepa Rajasekaran, Alvaro Baeza Garcia

  • 1Departments of Pharmacology, ‡Internal Medicine, §Chemistry, and the ∥Yale Cancer Center, Yale University , New Haven, Connecticut 06520-8066, United States.

Journal of Medicinal Chemistry
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Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...