CC chemokine receptor polymorphism CCR5Δ32 in Portuguese Behçet's disease patients
Andreia Bettencourt1, Bárbara Leal, Cláudia Carvalho
1UMIB, Instituto de Ciências Biomédicas Abel Salazar (ICBAS-UP), Porto, Portugal. ambettencourt@icbas.up.pt.
Objectives:
To investigate whether CCR5 deletion is associated with susceptibility to Behçet's disease (BD) in a Portuguese population.
Methods:
A total of 122 BD patients and 227 ethnically-matched controls were studied. Genotyping of the CCR5Δ32 polymorphisms was performed using polymerase chain reaction product sizing.
Results:
No significant differences were observed in the allelic frequencies of CCR532 between patients and controls (OR=0.820; p=0.512). Stratification for gender and for the presence of HLA-B*51 did not reveal any significant differences.
Conclusions:
These results indicate that CCR5Δ32 is unlikely to contribute to susceptibility to BD in Portuguese patients. This may be explained by the known functional redundancy of this signalling system.
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