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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

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Computer-assisted cognitive behavioral therapy for pregnant women with major depressive disorder

Deborah R Kim¹, Liisa Hantsoo, Michael E Thase

¹1 Penn Center for Women's Behavioral Wellness, Perelman School of Medicine at the University of Pennsylvania , Philadelphia, Pennsylvania.

Journal of Women'S Health (2002)

|October 1, 2014

Background:

Pregnant women with major depressive disorder (MDD) report that psychotherapy is a more acceptable treatment than pharmacotherapy. However, although results of several studies suggest that psychotherapy is an effective treatment for pregnant women, logistical barriers-including cost and traveling for weekly visits-can limit real-world utility. We hypothesized that computer-assisted cognitive behavior therapy (CCBT) would be both acceptable and would significantly decrease depressive symptoms in pregnant women with MDD.

Methods:

As a preliminary test of this hypothesis, we treated 10 pregnant women with MDD using a standardized CCBT protocol.

Results:

The pilot results were very promising, with 80% of participants showing treatment response and 60% showing remission after only eight sessions of CCBT.

Conclusion:

A larger, randomized controlled trial of CCBT in pregnant women with MDD is warranted.

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