Sequential one-pot access to molecular diversity through aniline aqueous borylation

Area of Science:

• Organic Chemistry
• Synthetic Chemistry

Background:

• Aniline borylation is a key reaction in organic synthesis.
• Achieving molecular diversity often requires multi-step processes.

Purpose of the Study:

• To develop a streamlined, one-pot method for generating molecular diversity.
• To integrate aniline aqueous borylation with subsequent chemical transformations.

Main Methods:

• A novel one-pot procedure was developed.
• The process combines aniline aqueous borylation with esterification, Suzuki-Miyaura coupling, hydrogenolysis, or Petasis borono-Mannich reactions.

Main Results:

• High molecular diversity was achieved in a single synthetic operation.
• The method demonstrates broad applicability by integrating multiple reaction types.

Conclusions:

• The developed one-pot process offers an efficient route to diverse organic molecules.
• This strategy simplifies complex synthesis, enabling rapid access to varied chemical structures.