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Updated: Apr 23, 2026

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CTLA4-Ig preserves thymus-derived T regulatory cells

Sarah M Ahmadi1, Markus A Hölzl, Edda Mayer

  • 11 Division Transplantation Immunology, Children's Cancer Research Institute, Vienna, Austria. 2 Division of Transplantation, Department of Surgery, Medical University Vienna, Austria. 3 Address correspondence to: Sarah Ahmadi, M.Sc., Children's Cancer Research Institute, Zimmermannplatz 10, A-1090 Vienna, Austria.

Transplantation
|October 1, 2014
PubMed
Summary

Cytotoxic T-lymphocyte-associated protein 4 immunoglobulin fusion proteins (CTLA4-Ig) do not impair regulatory T (Treg) cell function. This study shows CTLA4-Ig increases Treg cell frequency and maintains their suppressive activity in vitro.

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