Related Experiment Video

Updated: Apr 23, 2026

Updated Protocol for the Assembly and Use of the Minibioreactor Array (MBRA)
09:38

Updated Protocol for the Assembly and Use of the Minibioreactor Array (MBRA)

Published on: September 5, 2025

1.0K

[Vasculitis: New nomenclature of the Chapel Hill consensus conference 2012]

K Holl-Ulrich1

  • 1Konsultations- und Referenzzentrum für Vaskulitisdiagnostik, Institut für Pathologie, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland, konstanze.holl-ulrich@uksh.de.

Zeitschrift Fur Rheumatologie
|October 2, 2014
PubMed

Insights

The 2012 Chapel Hill Consensus Conference nomenclature updates vasculitis classification, separating ANCA-associated vasculitis and replacing eponyms with systematic names for better clarity in understanding these inflammatory vessel diseases.

Area of Science:

  • Rheumatology
  • Immunology
  • Pathology

Context:

  • Vasculitis classification has evolved significantly.
  • Previous nomenclature lacked clarity on etiopathology and disease course.
  • The 2012 Chapel Hill Consensus Conference (CHCC) aimed to address these limitations.

Purpose:

  • To present the revisions in the 2012 CHCC nomenclature for vasculitis.
  • To summarize recent advances in understanding vasculitis etiopathology and disease courses.
  • To highlight the inclusion of clinically relevant but less common vasculitis types.

Summary:

  • The 2012 CHCC nomenclature distinguishes anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis from immune complex small vessel vasculitis.
  • Eponyms like Wegener's granulomatosis are replaced by systematic names such as granulomatosis with polyangiitis.
  • The revised nomenclature incorporates updated knowledge on disease mechanisms and inflammation types, alongside vessel characteristics.

Impact:

  • Facilitates a more precise understanding of vasculitis subtypes and their underlying mechanisms.
  • Improves diagnostic accuracy and therapeutic strategies for vasculitis patients.
  • Provides a standardized framework for research and clinical practice in vasculitis.

More Related Videos

Author Spotlight: Getting an A with the 3Cs: Chromosome Conformation Capture for Undergraduates09:13

Author Spotlight: Getting an A with the 3Cs: Chromosome Conformation Capture for Undergraduates

Published on: May 12, 2023

5.5K
Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.22:27

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

414.4K

Related Concept Videos

Chair Conformation of Cyclohexane02:02

Chair Conformation of Cyclohexane

The chair conformation is the most stable form of cyclohexane due to the absence of angle and torsional strain. The absence of angle strain is a result of cyclohexane’s bond angle being very close to the ideal tetrahedral bond angle of 109.5° in its chair conformer. Similarly, the torsional strain is also absent owing to the perfectly staggered arrangement of bonds.
The hydrogen atoms linked to carbons are arranged in two different axial and equatorial orientations to achieve this...
16.0K
Coordination Compounds and Nomenclature02:54

Coordination Compounds and Nomenclature

In most main group element compounds, the valence electrons of the isolated atoms combine to form chemical bonds that satisfy the octet rule. For instance, the four valence electrons of carbon overlap with electrons from four hydrogen atoms to form CH4. The one valence electron leaves sodium and adds to the seven valence electrons of chlorine to form the ionic formula unit NaCl (Figure 1a). Transition metals do not normally bond in this fashion. They primarily form coordinate covalent bonds, a...
20.9K
Nomenclature of Aryl and Heterocyclic Amines01:10

Nomenclature of Aryl and Heterocyclic Amines

The simplest aromatic amine is phenylamine, which contains an –NH2 functionality directly attached to an aromatic ring. The name aniline is designated for this skeleton. As shown in Figure 1, the common names of the functionalized anilines involve prefixes ortho-, meta-, and para- to indicate the substitution position. Different functionalized aniline derivatives also have notable trivial names.
2.2K
Nomenclature of Secondary and Tertiary Amines01:12

Nomenclature of Secondary and Tertiary Amines

The secondary and tertiary amines are derivatives of ammonia, where two and three of its hydrogens are replaced by alkyl groups, respectively. Secondary and tertiary amines can be symmetrical with identical alkyl groups attached to the nitrogen atom or unsymmetrical when more than one type of alkyl group is present. The standard nomenclature of secondary and tertiary amines is similar to the names given to the primary amines. They are generally named alkylamines. As depicted in Figure 1, for...
4.2K
Nomenclature of Alkynes02:39

Nomenclature of Alkynes

Alkynes are unsaturated hydrocarbons characterized by the presence of carbon-carbon triple bonds and have a general formula CnH2n-2. The nomenclature of alkynes follows a set of rules similar to alkanes and alkenes; however, alkynes bear the suffix "-yne" instead of "-ane" or "-ene." There are two approaches to naming alkynes:
18.0K
Nomenclature of Carboxylic Acid Derivatives: Acid Halides, Esters, and Acid Anhydrides01:16

Nomenclature of Carboxylic Acid Derivatives: Acid Halides, Esters, and Acid Anhydrides

Naming Acid Halides
The IUPAC and common names of acid halides are derived from the corresponding carboxylic acids, by changing “ic acid” to “yl halide.” For example, as shown below, the IUPAC name ethanoyl chloride is derived from ethanoic acid, and the common name, acetyl chloride, is obtained from acetic acid.
5.2K