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Updated: Apr 23, 2026

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling
Published on: August 3, 2018
Focus issue: TGF-β and the mesenchymal transition in physiology and disease
Leslie K Ferrarelli1, Nancy R Gough2
1Associate Editor of Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA. lferrare@aaas.org.
Abstract:
The ability of cells to alter their phenotypic and morphological characteristics, known as cellular plasticity, is critical in normal embryonic development and adult tissue repair and contributes to the progression of diseases like organ fibrosis and cancer. Signaling mediated by the transforming growth factor-β (TGF-β) superfamily of extracellular protein ligands is one pathway that is integral to these processes. Content published in Science Signaling highlights the roles and complexities of TGF-β signaling in physiology and disease.
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