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Significance of AKT in gastric cancer (Review)

Takamitsu Sasaki1, Hiroki Kuniyasu2

  • 1Department of Gastroenterological Surgery, Fukuoka University School of Medicine, Jonan‑ku, Fukuoka 814‑0180, Japan.

International Journal of Oncology
|October 2, 2014
PubMed

Insights

The AKT pathway, crucial for cell growth and motility, is frequently activated in cancers, including gastric cancer. Targeting AKT offers a promising therapeutic strategy for cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Signaling

Background:

  • The AKT (also known as Protein Kinase B) serine/threonine kinase is activated downstream of integrin signaling.
  • Integrins are receptors for extracellular matrix components and bioactive substances that promote cell proliferation.
  • AKT activation is implicated in tumorigenesis, cell motility, invasion, and metastasis.

Purpose of the Study:

  • To provide a basic overview of AKT's role in normal and malignant tissues.
  • To discuss the specific role of AKT in gastric cancer.
  • To explore the potential of AKT as a therapeutic target in cancer.

Main Methods:

  • Literature review of existing research on AKT signaling in cancer.
  • Analysis of AKT's function in normal physiological processes.
  • In-depth examination of AKT's involvement in gastric cancer development and progression.

Main Results:

  • AKT plays a significant role in cell proliferation, survival, and motility.
  • Aberrant AKT activation is a common event in various cancers, contributing to tumor growth and metastasis.
  • The tumor microenvironment and cancer heterogeneity influence AKT's role.

Conclusions:

  • AKT is a critical regulator of cell functions relevant to cancer.
  • Understanding AKT signaling in the context of the tumor microenvironment is essential.
  • Targeting the AKT pathway represents a promising strategy for novel molecular-targeted cancer therapies, particularly in gastric cancer.

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