Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lateralization01:28

Lateralization

1.3K
Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.
1.3K
Higher Mental Functions of the Brain: Language01:10

Higher Mental Functions of the Brain: Language

6.0K
Language is a system of communication that allows the expression of thoughts, ideas, and feelings. The brain processes language in both hemispheres.
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
6.0K
Language and Cognition01:27

Language and Cognition

865
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
865
Cerebral Hemispheres01:05

Cerebral Hemispheres

3.6K
The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
3.6K
Components of Language01:24

Components of Language

838
Language, whether spoken, signed, or written, consists of specific components: lexicon and grammar. The lexicon is the vocabulary of a language, comprising its words. Grammar is the set of rules used to convey meaning through the lexicon. For example, English grammar adds “-ed” to most verbs to indicate past tense. Words are formed by combining phonemes, which are the basic sound units of a language. Different languages have different sets of phonemes (e.g., “ah” vs.
838
Complementation Tests00:49

Complementation Tests

4.9K
A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
4.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A three-arm randomised controlled trial comparing ultra-low intensity interventions for gratitude vs. things you do vs. waitlist control for depression and anxiety in health professionals.

Behaviour research and therapy·2026
Same author

A large language model framework for sample-free population synthesis.

PloS one·2026
Same author

Integrating enriched case data from national laboratory testing with population-based case-control analyses: a novel statistical likelihood-ratio methodology for PS4 applied to 325,345 breast cancer cases and 671,006 controls.

medRxiv : the preprint server for health sciences·2026
Same author

Impact of Restriction-Resumption Protocols on Mood and Anxiety in Healthy Adults: Randomized Controlled Trial.

JMIR formative research·2026
Same author

A Clinical Practice Update for the Management of Patients With Disorders of Gut-Brain Interaction and Altered Food Intake Behavior.

Neurogastroenterology and motility·2026
Same author

Postapproval Study for Brain-Responsive Neurostimulation for Drug-Resistant Focal Epilepsy: Three-Year Efficacy and Interim Safety Results.

Neurology·2026

Related Experiment Video

Updated: Apr 23, 2026

Examining Bilingual Language Control Using the Stroop Task
05:31

Examining Bilingual Language Control Using the Stroop Task

Published on: February 26, 2020

14.5K

Grammar tests increase the ability to lateralize language function in the Wada test.

Monika Połczyńska1, Susan Curtiss2, Particia Walshaw3

  • 1UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA, USA; Faculty of English, Adam Mickiewicz University, Poznań, Poland.

Epilepsy Research
|October 2, 2014
PubMed
Summary
This summary is machine-generated.

A new grammar test, CYCLE-N, shows promise in determining language dominance during the Wada test. This method offers a valuable tool for patients unable to speak during standard assessments, improving hemispheric lateralization accuracy.

Keywords:
EpilepsyGrammarIntracarotid amobarbital procedureLanguageWada test

More Related Videos

The Spatial Memory Game: Testing the Relationship Between Spatial Language, Object Knowledge, and Spatial Cognition
05:15

The Spatial Memory Game: Testing the Relationship Between Spatial Language, Object Knowledge, and Spatial Cognition

Published on: February 19, 2018

11.9K
Lexical Decision Task for Studying Written Word Recognition in Adults with and without Dementia or Mild Cognitive Impairment
06:48

Lexical Decision Task for Studying Written Word Recognition in Adults with and without Dementia or Mild Cognitive Impairment

Published on: June 25, 2019

8.7K

Related Experiment Videos

Last Updated: Apr 23, 2026

Examining Bilingual Language Control Using the Stroop Task
05:31

Examining Bilingual Language Control Using the Stroop Task

Published on: February 26, 2020

14.5K
The Spatial Memory Game: Testing the Relationship Between Spatial Language, Object Knowledge, and Spatial Cognition
05:15

The Spatial Memory Game: Testing the Relationship Between Spatial Language, Object Knowledge, and Spatial Cognition

Published on: February 19, 2018

11.9K
Lexical Decision Task for Studying Written Word Recognition in Adults with and without Dementia or Mild Cognitive Impairment
06:48

Lexical Decision Task for Studying Written Word Recognition in Adults with and without Dementia or Mild Cognitive Impairment

Published on: June 25, 2019

8.7K

Area of Science:

  • Neuroscience
  • Neurolinguistics
  • Epilepsy Research

Background:

  • Grammar assessment is crucial for language function but is underutilized in the Wada test.
  • The Wada test is a standard procedure for lateralizing brain function, particularly language.

Purpose of the Study:

  • To evaluate the efficacy of a novel grammar test (CYCLE-N) in enhancing language lateralization during the Wada test.
  • To determine if CYCLE-N can improve the identification of hemispheric dominance for language, especially in patients with limited verbal output.

Main Methods:

  • Sixteen epilepsy patients underwent Wada testing with standard language assessments and the CYCLE-N grammar test during the recovery phase.
  • Participants were selected based on left hemisphere language dominance in the encoding phase.
  • Ten patients received bilateral injections, while six had unilateral injections (left or right hemisphere).

Main Results:

  • The CYCLE-N test revealed more significant language deficits following left hemisphere injection compared to right hemisphere injection.
  • Standard language tests showed less pronounced differences between left and right hemisphere injections.
  • CYCLE-N demonstrated a statistically significant ability (p=0.01) to differentiate hemispheric effects, unlike standard tests (p=0.2).

Conclusions:

  • The CYCLE-N grammar test is more effective than standard tests in differentiating language lateralization during Wada testing.
  • This novel grammar assessment is particularly beneficial for patients who are too obtunded to speak during the encoding phase.
  • CYCLE-N shows potential as a valuable tool for assessing hemispheric dominance for language in clinical settings.