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Updated: Apr 23, 2026

Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model
Published on: April 1, 2019
Vascularized composite autograft for adult laryngotracheal stenosis and reconstruction
Jason T Rich1, David Goldstein1, Stephan K Haerle1
1Department of Otolaryngology - Head and Neck Surgery, University Health Network/Toronto General Hospital, University of Toronto, Ontario, Canada.
Background:
Adult laryngotracheal reconstruction for airway stenosis and after oncologic ablation can be extremely challenging.
Methods:
Patients with the above conditions not amenable to or refractory to conventional treatments were offered specialized reconstruction by wrapping a contoured costal cartilage graft with a vascularized microvascular carrier. All constructs were lined with buccal mucosa grafts. Decannulation rates, quality of life questionnaires, and pulmonary function tests were performed and analyzed.
Results:
Eleven patients underwent this procedure, 6 for stenosis and 5 for laryngotracheal oncologic defects. Ten patients were successfully decannulated after the procedure (91%). Median time to decannulation was 4 months. At mean follow-up of 76 months, all evaluated patients had a serviceable voice, tolerated a normal diet, and had minimal subjective shortness of breath.
Conclusion:
Vascularized composite autograft can be successfully used to treat severe subglottic stenosis or reconstruct large laryngotracheal defects not amenable to or refractory to conventional treatments.
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