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Updated: Apr 23, 2026

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Published on: August 9, 2013
Mortality prediction by acute kidney injury biomarkers in comparison with serum creatinine
Takahiro Hiruma1, Toshifumi Asada, Miyuki Yamamoto
1Department of Emergency and Critical Care Medicine and.
Objectives:
To investigate the performance of acute kidney injury (AKI) biomarkers for mortality prediction.
Materials And Methods:
Cutoff values of urinary L-type fatty acid-binding protein (L-FABP) and N-acetyl-β-d-glucosaminidase (NAG) for AKI diagnosis in ICU were determined in the derivation cohort. The performance of these AKI biomarkers for mortality prediction was evaluated in the validation cohort with stratification of serum-creatinine based AKI diagnosis.
Results:
Mortality in the AKI patients diagnosed by serum creatinine was increased remarkably when urinary L-FABP and NAG were positive.
Conclusions:
These AKI biomarkers can specifically detect high-risk patients among creatinine-base diagnosed AKI.
Related Concept Videos
Acute Kidney Injury I: Introduction
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
Acute Kidney Injury III: Clinical Manifestations
Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance
Acute Kidney Injury V: Interprofessional Care

