Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

387
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
387
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

914
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
914
Fatigue01:21

Fatigue

1.1K
Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
1.1K
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

813
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
813
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

371
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
371
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

348
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
348

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Life's Essential 8: Cardiovascular Health Assessment Among Brazilian University Workers.

Workplace health & safety·2026
Same author

Risk factors associated with frailty and hypertension in older adults: a path analysis.

Geriatric nursing (New York, N.Y.)·2026
Same author

Napping Habit and Risk Factors for Cardiovascular Disease: Does It Matter if It Is Sunday?

Sleep science (Sao Paulo, Brazil)·2025
Same author

Factors associated with the fragmentation and stability of the rest-activity rhythm in adults and older adults.

Chronobiology international·2024
Same author

The impact of the COVID-19 pandemic on sleep disorders among Nursing professionals.

Revista latino-americana de enfermagem·2023
Same author

Sleep in pregnancy quarters: a longitudinal study.

Revista gaucha de enfermagem·2022

Related Experiment Video

Updated: Apr 23, 2026

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
09:25

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

18.8K

[Fatigue in the elderly undergoing chemotherapy].

Thalyta Cristina Mansano-Schlosser, Maria Filomena Ceolim

    Revista Brasileira De Enfermagem
    |October 2, 2014
    PubMed
    Summary

    Over 40% of elderly cancer patients experience significant fatigue during chemotherapy. Many found relief difficult, highlighting a need for better nursing interventions for cancer-related fatigue.

    Area of Science:

    • Oncology
    • Geriatrics
    • Nursing

    Context:

    • Cross-sectional survey of 140 elderly cancer patients (mean age 69.8) undergoing outpatient chemotherapy.
    • Utilized questionnaires for sociodemographic, clinical data, and the Piper Fatigue Scale-revised.

    Purpose:

    • To identify the presence and severity of fatigue in elderly cancer patients receiving chemotherapy.
    • To explore attributed causes and relief factors for fatigue in this population.

    Summary:

    • Fatigue was present in 42.9% of elderly cancer patients.
    • Primary causes included cancer (64.1%), chemotherapy (32.8%), and treatment (3.1%).
    • Reported relief factors were sleeping and prayer; 45% felt fatigue was unmanageable.

    Impact:

    More Related Videos

    Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
    08:56

    Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

    Published on: May 17, 2018

    8.6K
    A Mouse Model of Fatigue Induced by Peripheral Irradiation
    04:15

    A Mouse Model of Fatigue Induced by Peripheral Irradiation

    Published on: March 17, 2017

    7.4K

    Related Experiment Videos

    Last Updated: Apr 23, 2026

    The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
    09:25

    The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

    Published on: May 31, 2016

    18.8K
    Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
    08:56

    Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

    Published on: May 17, 2018

    8.6K
    A Mouse Model of Fatigue Induced by Peripheral Irradiation
    04:15

    A Mouse Model of Fatigue Induced by Peripheral Irradiation

    Published on: March 17, 2017

    7.4K
    • Highlights the high prevalence of fatigue in elderly cancer patients undergoing chemotherapy.
    • Underscores the need for nurses to proactively identify and manage cancer-related fatigue.
    • Suggests a gap in effective fatigue relief strategies for this demographic.